Endocrine Abstracts

Pituitary adenomas may show alterations of PI3K/Akt pathway. IGF2, binding the IGF1-R, is able to active it. LOI of IGF2 has been implicated in the pathogenesis of many tumours. Activation of PI3K produces phosphorylation of p27 and its cytoplasmic mislocalization. Loss of nuclear p27 was associated with worse prognosis. In this study we correlated IGF2 imprinting with activation of PI3K/Akt pathway in a series of 29 somatotropinomas. After surgery, tumors were embedded in RNA...

Adipocytes are cells highly specialized in storing excess energy as neutral lipids in lipid droplets (LDs). These organelles act not only as mere fat reservoirs, but also as active modulators of lipid storage and mobilization in response to hormonal signals. This role is accomplished through a plethora of proteins associated with the LD surface that spatially and temporally coordinate lipid metabolism and traffic on demand. Recently, we have shown that the LD-associated protei...

Objective: Modifications in lifestyle and diet are major contributors for the high prevalence of obesity. Very few longitudinal studies have evaluated the changes in body weight over time. Dynamic changes in body weight are also an important indicator of risk for type 2 diabetes. The aim of this study is to assess factors associated with weight gain in a population of Spanish adults.Methods: The study was undertaken in two population-based cohorts of Spa...

Introduction: Kisspeptins, the products of the Kiss1 gene that act via the receptor, GPR54 (or Kiss1R), are pivotal elements in the neuroendocrine control of GnRH neurons and, thereby, gonadotropin secretion. Extensive efforts have been devoted recently to elucidate the pharmacological effects and major putative regulators of the kisspeptin system. Yet, our knowledge on the potential interactions of kisspeptins with other key neurotransmitters involved in the central re...

Introduction: The autosomal dominant multiple endocrine neoplasia type 1 (MEN1), characterized by parathyroid hyperplasia (PH), neuroendocrine digestive tumours (NET) and pituitary adenomas (PA), is due to mutations in the tumor suppressor gene MEN1 encoding a 610-amino acid protein, menin. Guidelines recommend MEN1 mutational analysis in index cases with two or more MEN1-associated tumours, in first-degree relatives of mutation carriers and when clinical dat...